Williams has won 23 Grand Slam titles, the most for any woman in the Open Era.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
Australian Open WTA
|
Quarter Finals | Karolina Pliskova |
4-6
6-4 5-7 |
| 2019 |
Australian Open WTA
|
1/8 | Serena Williams |
1-6
6-4 4-6 |
| 2019 |
Australian Open WTA
|
1/16 | Serena Williams |
2-6
1-6 |
| 2019 |
Australian Open WTA
|
1/32 | Serena Williams |
2-6
2-6 |
| 2019 |
Australian Open WTA
|
1/64 | Serena Williams |
0-6
2-6 |
| 2018 |
US Open WTA
|
Final | Naomi Osaka |
2-6
4-6 |
| 2018 |
US Open WTA
|
Semi Finals | Serena Williams |
6-3
6-0 |
| 2018 |
US Open WTA
|
Quarter Finals | Serena Williams |
6-4
6-3 |
| 2018 |
US Open WTA
|
1/8 | Serena Williams |
0-6
6-4 3-6 |
| 2018 |
US Open WTA
|
1/16 | Serena Williams |
6-1
6-2 |
| 2018 |
US Open WTA
|
1/32 | Serena Williams |
6-2
6-2 |
| 2018 |
US Open WTA
|
1/64 | Serena Williams |
6-4
6-0 |
| 2018 |
Western & Southern Open
|
1/16 | Petra Kvitova |
6-3
2-6 6-3 |
| 2018 |
Western & Southern Open
|
1/32 | Serena Williams |
1-6
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Australian Open
|
1/32 | David Goffin |
4-6
0-6 3-6 |
| 2017 |
Australian Open
|
1/64 | Radek Stepanek |
2-6
6-7 3-6 |
| 2017 |
Australian Open, Qualification
|
1/16 | Radek Stepanek |
6-2
6-4 |
| 2017 |
Australian Open, Qualification
|
1/32 | Radek Stepanek |
6-3
6-7 8-6 |
| 2017 |
Australian Open, Qualification
|
1/64 | Radek Stepanek |
6-3
6-7 6-2 |
