It was the fifth ATP title for 2011 champion Wawrinka, who is presently ranked a career-best eighth. The Swiss moved past 300 wins on the ATP circuit during this tournament.
"It's big winning five tournaments," Wawrinka said. "I've improved a lot through the last year and am trying my best to give the top guys a run for their money."
Roger-Vasselin, looking for a maiden ATP title in his second final, started competitively but made several unforced errors in a bid to raise his game as Wawrinka took control midway into the match.
Wawrinka was the more dominating of the two on serve but had to wait till the 11th game to go a break up against the seventh-seeded Roger-Vasselin.
Wawrinka broke in the first game of the second set with a fine forehand passing shot at deuce and Roger-Vasselin then hitting into the net. More unforced errors by the Frenchman in the fifth game gave Wawrinka another break to virtually wrap up the match.
"I tried everything but Stan was simply too good," Roger-Vasselin said.