MUNICH (AP) Two-time former champion Philipp Kohlschreiber was knocked out in the first round of the BMW Open on Tuesday, losing 7-5, 2-6, 6-4 to Denis Istomin.
The 55th-ranked Istomin saved 11 of 14 break points to win in just over two hours, setting up a second-round meeting with Australian Marinko Matosevic.
It was the Uzbek's third win in three matches against fifth-seeded Kohlschreiber, the 2007 and 2012 tournament winner.
There were further upsets when Germany's Jan-Lennard Struff defeated sixth-seeded Feliciano Lopez 6-3, 6-4 and qualifier Thomaz Bellucci beat No. 8 seed Ivan Dodig 7-6 (0), 6-4.
Also, Martin Klizan eased past Dudi Sela 6-1, 6-2 to set up a second-round clash with third-seeded Mikhail Youzhny, and Jurgen Melzer beat wild card Alexander Zverev by the same score.