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Fifteen years ago, a 17-year-old Maria Sharapova stormed through a stacked Wimbledon draw to claim her first major title. Unfortunately for the five-time major champion, there will not be a chance of rekindling that magical run.

Pauline Parmentier led 4-6, 7-6 (4), 5-0 in their first-round encounter Tuesday before Sharapova retired with what appeared to be a left wrist/arm injury. The Russian was two points away from advancing up 5-2, 30-30 in the second set, and also served for the match at 5-3.

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Sharapova falls in opener nearly 15 years after first Wimbledon title

Sharapova falls in opener nearly 15 years after first Wimbledon title

In 2004, Sharapova had the daunting task of facing world No. 1 Serena Williams in the final but was not fazed, capturing the Wimbledon trophy with a 6-1, 6-4 triumph over the two-time defending champion. That impressive display was her first of two successive victories against Williams, before the American began an 18-match win streak in their head-to-head series.

Sharapova made her return from a five-month injury absence two weeks ago in Mallorca. She fell in the second round to the reigning Wimbledon champion Angelique Kerber in straight sets.

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Sharapova falls in opener nearly 15 years after first Wimbledon title

Sharapova falls in opener nearly 15 years after first Wimbledon title