WATCH: Tennis Channel Live discusses Serena Williams' final match of her illustrious career.

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NEW YORK—With Serena Williams’ farewell from professional tennis dominating the headlines far beyond the sports world, her run to the US Open third round was the defining moment of the Grand Slam’s first week.

It seemed like no one wanted to miss a moment of the action, with the USTA announcing record attendance figures during Serena’s matches, and then breaking those records in subsequent sessions.

At Arthur Ashe Stadium, where the stands were packed with celebrities, the buzz of the record crowds was almost palpable—especially since they were also, well, quite buzzed, too.

With so many tennis fans in their feelings, it’s no surprise that there were a lot of Honey Deuces being served up during this US Open—even more so on Friday night, when the 23-time Grand Slam champion was defeated by Ajla Tomljanovic to begin her “evolution” away from professional tennis.

The tournament’s signature cocktail, the Honey Deuce is to the US Open what a Pimm's Cup is to Wimbledon or a mint julep is to the Kentucky Derby. Even with its astronomically high price tag of $22 a pop, the Honey Deuce remains wildly popular for US Open fans and collectors:

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Made with Grey Goose vodka, freshly squeezed lemonade, and Chambord raspberry liqueur, and served over ice, the Honey Deuce is garnished with a delightful spear of three green melon balls and comes in a souvenir glass that lists all of the previous men’s and women’s singles champions.

But by Sunday, the first signs of the post-Serena hangover were starting to show—and it was the tournament’s beloved cocktail that was hit the hardest.

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As ESPN’s Howard Bryant first reported from Louis Armstrong Stadium, the US Open’s signature cocktail was running out of its signature souvenir cup.

But this was just the first wave in a ripple effect that was soon felt throughout the grounds, with multiple Grey Goose vendors around the grounds echoing the same thing:

By the end of the day, with Honey Deuces being served in generic plastic cups for the discounted price of $20, practically the only place the souvenir cups could be found was in Arthur Ashe Stadium as vendors were being instructed to save them for the night session.

That was a good call, as Nick Kygrios and defending Daniil Medvedev kicked off Sunday evening’s play in front of a packed house in a match that featured the world No. 1 going out in four sets. But even these last few cups quickly ran out, too.

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Of course, that’s all a part of the appeal of the commemorative cups. Eventually they do run out—usually by the final weekend of the tournament, to be fair—making them a prized souvenir for the ones who manage to snag them.

By Monday morning, however, it seemed like all was back to normal in the world of the Honey Deuce: Like magic, all around the grounds the pink drinks were being served in the right cups again.

But after the Great Honey Deuce Cup Shortage of Week 1, US Open fans would be wise to hoard their precious collectibles for when the real cup crunch hits.