"There could be a little mental aspect in our match,” said Isner. "I say that because our rivalry, what have you, goes back way before the pro tour. We played each other in college probably three, four, five times.
"We've been lined up against each other for about 14 years now, because he left Illinois when I left Georgia. We've been doing it ever since."
Both have been having career seasons. South Africa's Anderson reached the final of the 2017 US Open, and is at a career-high No. 8 in the rankings. Isner recently won Miami, the biggest title of his career, and is No. 10 in the rankings.
"For me this matchup, and I think for him as well, is especially cool. It's a very nice spotlight on college tennis, that one of us, no matter what, is going to be playing in the Wimbledon final," said Isner. "It's pretty cool."