BRUSSELS (AP) Fourth-seeded Jelena Jankovic of Serbia was upset by Sofia Arvidsson of Sweden 3-6, 6-3, 6-3 at the Brussels Open on Wednesday.

It was the latest setback on clay this spring for Jankovic, who failed to progress beyond the second round of three of the four tournaments she has played on the surface. Last week, she reached the quarterfinals in Rome for her best clay-court result this year.

Jankovic reached the semifinals at the French Open three of the last four years.

Second-seeded Vera Zvonareva survived an early scare to beat Galina Voskoboeva of Kazakhstan 2-6, 6-4, 6-3 and advance to the quarterfinals.

World No. 1 Caroline Wozniacki opened her bid for the inaugural Brussels Open title by beating American Varvara Lepchenko 6-4, 7-6 (5).

In an all-Belgian contest, sixth-seeded Yanina Wickmayer edged 17-year-old qualifier Alison Van Uytvanck 7-6 (2), 6-4. Wickmayer will next play Wozniacki, who has beaten the Belgian twice on clay this spring.

French Open champion Francesca Schiavone reached the quarterfinals by beating American Irina Falconi 6-4, 6-4. She will next take Ayumi Morita of Japan, who edged Casey Dellacqua of Australia 1-6, 6-0, 7-5.

Eighth-seeded Peng Shuai of China beat qualifier Abigail Spears of the U.S. 6-2, 6-0.

The clay-court tournament is the last warmup for the French Open, which begins Sunday.