WATCH: Serena Williams discusses her second-round win over Mihaela Buzarnescu on Wednesday.

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Serena Williams vs. Danielle Collins

To say the intensity will be high in this all-American clash is likely to be an understatement. Williams and Collins are two of the most expressively fierce competitors in tennis, and neither minds sending a message down to the other side of the court—whether it be with a scream, a fist-pump, or a “Come on!” Serena won their only meeting in Melbourne earlier this year, in a match that was decided by a super-tiebreaker rather than a third set. Collins, who thrives on pace, held her own against Serena’s power that day, and after reaching the quarterfinals at Roland Garros last year, she should also feel good about her game on clay. As for Serena, she might like her chances in this tournament a little more now that the top two seeds, Ash Barty and Naomi Osaka, aren’t in it anymore. Will that motivate her, or make her more nervous? Or both? So far she hasn’t had her A-game, exactly, but she has had her A-determination. That’s usually enough for her. Winner: Serena

Daniil Medvedev vs. Reilly Opelka

After winning the first two matches of his career at Roland Garros this week, Medvedev says he’s feeling “hopeful” and “capable of doing big things” here. That’s a far cry from the player who was cursing the clay beneath his feet in Madrid and Rome. In the third round, though, I don’t think Medvedev will be worrying that much about the surface. His biggest headache will be his opponent’s serve. Medvedev is a good returner, but the 6’11” Opelka has given him fits in the past. In their first two meetings. Medvedev escaped in third-set tiebreakers; in their third match, Opelka came back to beat him 6-4 in the third set. And while Medvedev has been getting more comfortable, so has the American, who made the semifinals in Rome. This one could come down to just a few points; if Medvedev wins easily, it might be a sign of bigger things to come for him. Winner: Medvedev

Opelka and his tie-dye Fila kit have been dominating opponents

Opelka and his tie-dye Fila kit have been dominating opponents

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Stefanos Tsitsipas vs. John Isner

Judging from their head-to-head, it seems as though Tsitsipas has slowly figured out how to deal with Isner and the challenge his big serve presents. The American won their first two meetings, including a straight-setter at Wimbledon in 2018. Since then, however, Tsitsipas has won three in a row. The most lopsided came with a 6-3, 6-2 victory in Acapulco; not many people can break Isner often enough to record a score like that against him. Over the last two months, Tsitsipas’s level has only risen on clay, and with the Big 3 in the other half of the draw, he has to like his chances to make his first major final. At 36, Isner can still be a threat on clay; he beat Andrey Rublev in Madrid last month. And Tsitsipas’s one-handed backhand will be a prime target for his first and second serves. But this seems to be the season of the Greek. Winner: Tsitsipas