WATCH: Novak Djokovic makes history.

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If one of the Big Three wins the US Open in September—and considering they’ve collectively won 60 of the last 72 Grand Slam tournaments, that seems likely—one of them will end 2021 with 21 major titles.

That’s because Novak Djokovic joined Roger Federer and Rafael Nadal with 20 Slams on Sunday, defeating Matteo Berrettini for his sixth Wimbledon title, 6-7 (4), 6-4, 6-4, 6-3.

The symmetry and absurdity of the numbers makes for a US Open like no other, with history at stake in a way even this titanic trio has yet to experience.

Federer has won the US Open five times, but not since 2008. Nadal has won it four times (it’s his second most-fruitful major), and is the most recent champion from this triad. Djokovic last won it in 2018, over Juan Martin del Potro.

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On top of all that, Djokovic has a chance to complete a calendar-year Grand Slam, something no man has done since Rod Laver, in 1969. The Aussie accomplished that at the West Side Tennis Club in Forest Hills, on grass—a surface the Serb probably wouldn't mind the US Open reverting to, after his latest triumph at the All England Club.

"Winning Wimbledon was always the biggest dream of mine when I was a kid," said Djokovic, who is now a three-time defending champion at Wimbledon and the Australian Open.

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"It means none of us three will stop," Djokovic added, with a laugh, when asked about the 20-20-20 tie. "They are the two most important players that I have ever faced in my career. They are the reason where I am today. They helped me realize what I needed to do to improve physically, mentally, tactically.

"Something shifted at the end of 2010, beginning of 2011. The last 10 years have been an incredible journey that is not stopping here."