Top seed Caroline Wozniacki and Maria Sharapova could meet in the fourth round of the U.S. Open, while the two unseeded No. 1s, Dinara Safina and Ana Ivanovic, have both landed in defending champ and second seed Kim Clijsters's quarter of the draw.
Svetlana Kuznetsova is also in Wozniacki's quarter, while Jelena Jankovic, Vera Zvonareva and Agnieszka Radwanska are the top seeds in the second quarter.
The third quarter of the draw could culminate in a potential faceoff between Venus Williams and Victoria Azarenka. Azarenka could meet rising Russian Anastasia Pavlyuchenkova in the third round, and possibly French Open champ Francesca Schiavone in the fourth. Last year's quarterfinalist Melanie Oudin is also in Schiavone's section and begins against a qualifier.
At the bottom of the draw, Clijsters is slated to meet Sam Stosur in the quarterfinals, though Elena Dementieva, Dinara Safina and Alisa Kleybanova are also in Stosur's section. Clijsters could meet Ivanovic in the fourth round.
First round matches of note include Daniela Hantuchova vs. Safina, Sharapova vs. Jarmila Groth, Jelena Jakovic vs. rising Romanian Simona Halep, Alize Cornet vs. Kaia Kanepi, Andrea Petkovic vs. Nadia Petrova and Sabine Lisicki vs. Coco Vandeweghe.
The full draw can be viewed here.