Donna Vekic edged No. 3 seed Aryna Sabalenka, rallying from 2-4 down in the final set to prevail, 6-4, 3-6, 7-6 (3).
World No. 1 Novak Djokovic had no trouble in advancing past Jan-Lennard Struff, 6-4, 6-3, improving to 6-0 against the German.
Taking on sixth seed Iga Swiatek, Paula Badosa outclassed the 2020 Roland Garros champion, 6-3, 7-6 (4).
Second seed Daniil Medvedev blitzed Sumit Nagal, 6-2, 6-1, to line up a third-round clash with 15th seed Fabio Fognini.
Alison Van Uytvanck surged past No. 10 seed Petra Kvitova, 5-7, 6-3, 6-0, to eliminate the lone Olympic medalist in the women’s singles draw.