Williams is playing her first clay tournament outside Rome and Roland Garros since 2015.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Emilia-Romagna Open
|
1/16 | Anna Karolina Schmiedlova |
5-7
6-2 6-2 |
| 2021 |
Madrid Open
|
1/32 | Jennifer Brady |
2-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
