Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2014 |
Wimbledon, Qualification
|
1/64 | Marco Chiudinelli |
3-2
|
| 2014 |
Roland Garros, Qualification
|
1/16 | Andreas Haider-Maurer |
6-0
6-1 |
| 2014 |
Roland Garros, Qualification
|
1/32 | Eric Prodon |
4-6
6-1 13-11 |
| 2014 |
Roland Garros, Qualification
|
1/64 | Eric Prodon |
7-6
6-3 |
| 2012 |
Tampere
|
Final | Joao Sousa |
7-6
6-4 |
| 2012 |
Tampere
|
Semi Finals | Eric Prodon |
6-2
6-2 |
| 2012 |
Tampere
|
1/16 | Eric Prodon |
2-6
5-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
