Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Miami Open
|
1/32 | Nicolas Mahut |
4-6
7-5 4-6 |
| 2015 |
Western & Southern Open, Qualification
|
1/7 (Special Qual) | Nicolas Mahut |
2-6
4-6 |
| 2014 |
Topshelf Open
|
1/8 | Nicolas Mahut |
6-2
7-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open, Qualification
|
1/24 (Special Qual) | Jason Jung |
6-4
3-6 6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
