Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2007 |
SAP Open
United States, California, San Jose |
Championship | Vince Spadea |
6-4
5-7 6-7 |
| 2005 |
Pilot Pen Tennis
|
Championship | Feliciano Lopez |
6-7
6-3 6-4 |
| 2002 |
Rakuten Japan Open Tennis Championships
|
Championship | Vince Spadea |
3-6
0-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Andalucia Open
|
1/16 | Feliciano Lopez |
6-4
6-4 |
| 2021 |
Miami Open
|
1/64 | Alexei Popyrin |
4-6
6-7 |
| 2021 |
Mexican Open
|
1/16 | Miomir Kecmanovic |
6-4
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2010 |
Campell's Hall of Fame Tennis Championships, Qualification
|
Championship | Santiago Gonzalez |
6-4
3-6 6-3 |
