Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/16 | Andrey Rublev |
7-5
6-2 6-3 |
| 2021 |
Australian Open ATP
|
1/32 | Feliciano Lopez |
5-7
3-6 6-3 7-5 6-4 |
| 2021 |
Great Ocean Road Open
|
1/32 | Kevin Anderson |
4-6
5-7 |
| 2020 |
Rolex Paris Masters
|
1/16 | Rafael Nadal |
4-6
7-6 6-4 |
| 2020 |
Rolex Paris Masters
|
1/32 | Feliciano Lopez |
6-7
1-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2015 |
US Open, Qualification WTA
|
1/64 | Mayo Hibi |
6-3
1-6 2-6 |
| 2015 |
Wimbledon WTA
|
1/64 | Urszula Radwanska |
2-6
1-6 |
| 2015 |
Family Circle Cup
|
1/32 | Madison Brengle |
7-6
4-6 2-6 |
