Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/16 | Andrey Rublev |
7-5
6-2 6-3 |
| 2021 |
Australian Open ATP
|
1/32 | Feliciano Lopez |
5-7
3-6 6-3 7-5 6-4 |
| 2021 |
Great Ocean Road Open
|
1/32 | Kevin Anderson |
4-6
5-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Lyon Open
|
1/8 | Greet Minnen |
6-4
2-6 3-6 |
| 2021 |
Lyon Open
|
1/16 | Arantxa Rus |
7-6
6-4 |
| 2021 |
Australian Open WTA
|
1/64 | Iga Swiatek |
6-1
6-3 |
| 2021 |
Yarra Valley Classic
|
1/32 | Venus Williams |
1-6
3-6 |
