Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
US Open
United States, New York, Flushing Meadows |
1/32 | Joao Sousa |
2-6
4-6 6-1 5-7 |
| 2015 |
Rakuten Japan Open Tennis Championships
|
1/16 | Joao Sousa |
6-4
4-6 6-1 |
| 2015 |
AEGON Championships
|
1/16 | Feliciano Lopez |
3-6
4-6 |
| 2013 |
Roland Garros
|
1/32 | Feliciano Lopez |
3-6
6-3 6-4 6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/16 | Andrey Rublev |
7-5
6-2 6-3 |
| 2021 |
Australian Open ATP
|
1/32 | Feliciano Lopez |
5-7
3-6 6-3 7-5 6-4 |
| 2021 |
Great Ocean Road Open
|
1/32 | Kevin Anderson |
4-6
5-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Argentina Open
|
1/16 | Sumit Nagal |
2-6
0-6 |
| 2021 |
Cordoba Open
|
1/16 | Roberto Carballes Baena |
6-3
6-1 |
