Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
Davis Cup Group 2 - Europe/Africa
|
Championship | Jarkko Nieminen |
3-6
6-3 1-6 6-7 |
| 2015 |
if...Stockholm Open
|
1/16 | Nicolas Almagro |
3-6
7-6 6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
