Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
Rome2
|
1/8 | Elias Ymer |
7-5
7-6 |
| 2016 |
Rome2
|
1/16 | Filippo Volandri |
6-2
6-3 |
| 2016 |
Genova
|
1/16 | Danilo Petrovic |
7-5
3-0 |
| 2016 |
Como
|
1/16 | Marco Cecchinato |
2-6
7-6 3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
