Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2014 |
US Open, Qualification
|
1/16 | Niels Desein |
6-7
3-6 |
| 2014 |
US Open, Qualification
|
1/32 | Oscar Hernandez |
6-3
1-6 6-4 |
| 2014 |
US Open, Qualification
|
1/64 | Oscar Hernandez |
3-6
3-6 |
| 2014 |
Roland Garros, Qualification
|
1/64 | Damir Dzumhur |
1-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
