Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2015 |
Australian Open
|
1/32 | Steve Johnson |
3-6
4-6 2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2020 |
Davis Cup Qualifying Round
|
Championship | Juan Ignacio Londero |
7-6
3-6 2-6 |
| 2020 |
Bangkok 2
|
1/16 | Denis Istomin |
6-3
7-6 |
| 2020 |
Bangkok 2
|
1/32 | Santiago Giraldo |
6-0
4-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
