Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2011 |
Guayaquil
|
Championship | Guido Pella |
6-4
3-6 6-1 |
| 2011 |
Belo Horizonte
|
Championship | Marco Trungelliti |
6-7
3-6 |
| 2011 |
Belo Horizonte
|
Championship | Brian Dabul |
6-2
6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
