Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Coupe Banque Nationale
|
1/8 | Alison van Uytvanck |
6-4
7-6 |
| 2017 |
Coupe Banque Nationale
|
1/16 | Marina Erakovic |
6-4
6-1 |
| 2017 |
US Open, Qualification WTA
|
1/64 | Fanny Stollar |
4-6
2-6 |
| 2017 |
Bank of the West Classic
|
1/16 | Ana Konjuh |
3-6
0-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/16 | Andrey Rublev |
7-5
6-2 6-3 |
| 2021 |
Australian Open ATP
|
1/32 | Feliciano Lopez |
5-7
3-6 6-3 7-5 6-4 |
| 2021 |
Great Ocean Road Open
|
1/32 | Kevin Anderson |
4-6
5-7 |
