Muguruza was fresh off a runner-up finish at the Qatar Total Open over the weekend.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Madrid Open, Qualification
|
1/24 (Special Qual) | Anastasija Sevastova |
3-6
6-4 6-3 |
| 2021 |
Volvo Car Open
|
1/32 | Coco Gauff |
6-3
6-0 |
| 2021 |
Miami Open
|
1/32 | Aryna Sabalenka |
6-0
3-6 6-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Internazionali BNL d'Italia, Qualification
|
1/16 | Andrea Petkovic |
6-4
5-7 6-3 |
| 2021 |
Madrid Open
|
1/32 | Daria Kasatkina |
6-4
4-6 6-7 |
