Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
Wuhan Tennis Open, Qualification
|
1/16 | Pauline Parmentier |
1-6
1-3 |
| 2016 |
KDB Korea Open
South Korea, Seoul |
1/16 | Sara Sorribes Tormo |
6-1
6-3 |
| 2016 |
Japan Women's Open
Japan, Tokyo |
1/16 | Kurumi Nara |
2-6
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
