Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Delray Beach Open
|
Quarter Finals | Juan Martin del Potro |
5-7
5-7 |
| 2016 |
Delray Beach International Tennis Championships
|
Semi Finals | Sam Querrey |
7-5
7-5 |
| 2011 |
Valencia Open 500
|
Championship | Juan Martin del Potro |
6-2
7-5 |
| 2009 |
Heineken Open
New Zealand, Auckland |
Championship | Juan Martin del Potro |
6-4
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
Queen's Club Championships
|
1/8 | Feliciano Lopez | |
| 2019 |
Queen's Club Championships
|
1/16 | Juan Martin del Potro |
7-5
6-4 |
| 2019 |
Roland Garros ATP
|
1/8 | Karen Khachanov |
7-5
6-3 3-6 6-3 |
| 2019 |
Roland Garros ATP
|
1/16 | Juan Martin del Potro |
4-6
4-6 0-6 |
| 2019 |
Roland Garros ATP
|
1/32 | Juan Martin del Potro |
7-5
4-6 2-6 7-6 2-6 |
| 2019 |
Roland Garros ATP
|
1/64 | Juan Martin del Potro |
6-3
2-6 1-6 4-6 |
| 2019 |
Italian Open
|
Quarter Finals | Novak Djokovic |
4-6
7-6 6-4 |
| 2019 |
Italian Open
|
1/8 | Juan Martin del Potro |
4-6
4-6 |
| 2019 |
Italian Open
|
1/16 | Juan Martin del Potro |
4-6
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yen-Hsun Lu |
3-6
4-6 |
| 2021 |
Australian Open ATP
|
1/64 | Lorenzo Sonego |
5-7
4-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/16 | Stefano Travaglia |
7-6
3-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Sam Querrey |
4-6
7-6 6-0 |
