Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
US Open
United States, New York, Flushing Meadows |
1/32 | Juan Martin del Potro |
6-7
3-6 2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
Queen's Club Championships
|
1/8 | Feliciano Lopez | |
| 2019 |
Queen's Club Championships
|
1/16 | Juan Martin del Potro |
7-5
6-4 |
| 2019 |
Roland Garros ATP
|
1/8 | Karen Khachanov |
7-5
6-3 3-6 6-3 |
| 2019 |
Roland Garros ATP
|
1/16 | Juan Martin del Potro |
4-6
4-6 0-6 |
| 2019 |
Roland Garros ATP
|
1/32 | Juan Martin del Potro |
7-5
4-6 2-6 7-6 2-6 |
| 2019 |
Roland Garros ATP
|
1/64 | Juan Martin del Potro |
6-3
2-6 1-6 4-6 |
| 2019 |
Italian Open
|
Quarter Finals | Novak Djokovic |
4-6
7-6 6-4 |
| 2019 |
Italian Open
|
1/8 | Juan Martin del Potro |
4-6
4-6 |
| 2019 |
Italian Open
|
1/16 | Juan Martin del Potro |
4-6
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
