Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2013 |
Winston-Salem
|
1/8 | Sam Querrey |
6-4
6-7 6-7 |
| 2012 |
Campionati Internazionali d'Italia
|
1/32 | Sam Querrey |
7-6
5-7 6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yen-Hsun Lu |
3-6
4-6 |
| 2021 |
Australian Open ATP
|
1/64 | Lorenzo Sonego |
5-7
4-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/16 | Stefano Travaglia |
7-6
3-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Sam Querrey |
4-6
7-6 6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
Davis Cup Group 2 - Europe/Africa
|
Championship | Jarkko Nieminen |
3-6
6-3 1-6 6-7 |
| 2015 |
if...Stockholm Open
|
1/16 | Nicolas Almagro |
3-6
7-6 6-4 |
