Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Abierto Mexicano Telcel
|
1/8 | Sam Querrey |
6-2
6-3 |
| 2016 |
Rogers Cup
Canada, Ontario, Toronto |
1/16 | David Goffin |
4-6
1-2 |
| 2015 |
Rogers Cup
|
1/16 | David Goffin |
6-4
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yen-Hsun Lu |
3-6
4-6 |
| 2021 |
Australian Open ATP
|
1/64 | Lorenzo Sonego |
5-7
4-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/16 | Stefano Travaglia |
7-6
3-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Sam Querrey |
4-6
7-6 6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Monte Carlo Masters
|
1/8 | David Goffin |
6-4
7-6 |
| 2021 |
Monte Carlo Masters
|
1/16 | David Goffin |
6-4
6-0 |
| 2021 |
Monte Carlo Masters
|
1/32 | David Goffin |
6-4
3-6 6-0 |
| 2021 |
Miami Open
|
1/32 | James Duckworth |
6-3
6-1 |
| 2021 |
Dubai Tennis Championships
|
1/16 | Kei Nishikori |
6-3
7-6 |
