Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2020 |
Australian Open ATP
|
1/64 | Sam Querrey |
6-3
6-4 6-4 |
| 2015 |
Roland Garros
|
1/64 | Borna Coric |
7-6
6-3 0-6 6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yen-Hsun Lu |
3-6
4-6 |
| 2021 |
Australian Open ATP
|
1/64 | Lorenzo Sonego |
5-7
4-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/16 | Stefano Travaglia |
7-6
3-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Sam Querrey |
4-6
7-6 6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Rotterdam Open
|
Semi Finals | Marton Fucsovics |
4-6
1-6 |
| 2021 |
Rotterdam Open
|
Quarter Finals | Borna Coric |
7-6
7-6 |
| 2021 |
Rotterdam Open
|
1/8 | Borna Coric |
3-6
2-6 |
