Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yen-Hsun Lu |
3-6
4-6 |
| 2021 |
Australian Open ATP
|
1/64 | Lorenzo Sonego |
5-7
4-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/16 | Stefano Travaglia |
7-6
3-6 4-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Sam Querrey |
4-6
7-6 6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/8 | Anastasija Sevastova |
6-1
7-5 |
| 2021 |
Miami Open
|
1/16 | Ana Konjuh |
6-4
2-6 6-2 |
| 2021 |
Miami Open
|
1/32 | Ana Konjuh |
4-6
2-6 |
| 2021 |
Miami Open
|
1/64 | Ana Konjuh |
6-7
5-7 |
| 2021 |
St. Petersburg Ladies Trophy, Qualification
|
1/12 (Special Qual) | Ana Konjuh |
3-6
4-6 |
| 2021 |
Dubai Duty Free Tennis Championships
|
1/32 | Amanda Anisimova |
6-2
6-2 |
