Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2016 |
Monterrey Open, Qualification
|
1/16 | Viktorija Golubic |
4-6
5-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Tallahassee
|
1/16 | Jason Jung |
6-2
3-6 4-6 |
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
