Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Volvo Car Open
|
1/32 | Leylah Fernandez |
3-6
1-6 |
| 2021 |
Miami Open
|
1/64 | Andrea Petkovic |
7-5
6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Andalucia Open
|
1/16 | Feliciano Lopez |
6-4
6-4 |
| 2021 |
Miami Open
|
1/64 | Alexei Popyrin |
4-6
6-7 |
| 2021 |
Mexican Open
|
1/16 | Miomir Kecmanovic |
6-4
6-4 |
