Kvitova and Muguruza were playing in Charleston for the first time since 2018 and 2013.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2015 |
Mutua Madrid Open
|
1/32 | Petra Kvitova |
3-6
6-1 6-4 |
| 2013 |
BNP Paribas Open
United States, California, Indian Wells |
1/32 | Petra Kvitova |
6-4
3-6 6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open, Qualification
|
1/12 (Special Qual) | Tsvetana Pironkova |
0-6
3-6 |
| 2021 |
Miami Open, Qualification
|
1/24 (Special Qual) | Olga Govortsova |
6-4
1-6 6-7 |
| 2021 |
Monterrey Open, Qualification
|
1/12 (Special Qual) | Kaja Juvan |
6-2
4-6 6-2 |
| 2021 |
Abierto de Guadalajara, Qualification
|
1/6 (Special Qual) | Caroline Dolehide |
6-7
7-5 6-7 |
| 2021 |
Abierto de Guadalajara, Qualification
|
1/12 (Special Qual) | Olga Govortsova |
6-0
6-2 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Volvo Car Open
|
1/8 | Danka Kovinic |
6-4
6-1 |
| 2021 |
Volvo Car Open
|
1/16 | Petra Kvitova |
6-7
2-6 |
| 2021 |
Miami Open
|
1/8 | Elina Svitolina |
6-2
5-7 5-7 |
| 2021 |
Miami Open
|
1/16 | Petra Kvitova |
6-1
6-2 |
| 2021 |
Miami Open
|
1/32 | Petra Kvitova |
6-0
6-4 |
| 2021 |
Dubai Duty Free Tennis Championships
|
1/16 | Jil Teichmann |
2-6
4-3 |
