Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2020 |
US Open ATP
|
1/32 | Adrian Mannarino |
7-6
7-5 6-2 |
| 2016 |
Swiss Indoors Basel
Switzerland, Basel |
1/16 | Jack Sock |
3-6
3-6 |
| 2015 |
Rogers Cup
|
1/32 | Jack Sock |
6-2
2-6 7-6 |
| 2014 |
Delray Beach International Tennis Championships
|
1/16 | Adrian Mannarino |
4-6
2-6 |
| 2014 |
U.S. National Indoor Tennis Championships
United States, Tennessee, Memphis |
1/16 | Jack Sock |
7-5
1-6 7-6 |
| 2014 |
Heineken Open
New Zealand, Auckland |
1/16 | Jack Sock |
6-3
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Barcelona Open
|
1/16 | Albert Ramos-Vinolas |
4-6
4-6 |
| 2021 |
Monte Carlo Masters
|
1/32 | Federico Delbonis |
7-5
6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Tallahassee
|
1/16 | Jason Jung |
6-2
3-6 4-6 |
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
