Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
BNP Paribas Open
|
Quarter Finals | Jack Sock |
6-3
2-6 6-2 |
| 2014 |
Shanghai Rolex Masters
|
1/16 | Jack Sock |
7-6
6-4 |
| 2013 |
Citi Open
|
1/16 | Kei Nishikori |
5-7
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/16 | Stefanos Tsitsipas |
3-6
6-3 1-6 |
| 2021 |
Miami Open
|
1/32 | Kei Nishikori |
7-6
5-7 6-4 |
| 2021 |
Dubai Tennis Championships
|
Quarter Finals | Lloyd Harris |
6-1
3-6 6-3 |
| 2021 |
Dubai Tennis Championships
|
1/8 | Kei Nishikori |
4-6
4-6 |
| 2021 |
Dubai Tennis Championships
|
1/16 | Kei Nishikori |
6-3
7-6 |
| 2021 |
Dubai Tennis Championships
|
1/32 | Kei Nishikori |
3-6
6-3 6-4 |
| 2021 |
Open 13 Provence
|
1/16 | Pierre-Hugues Herbert |
1-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
