Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Australian Open, Qualification WTA
|
1/48 (Special Qual) | Tatjana Maria |
6-1
6-2 |
| 2016 |
Brisbane International, Qualification
|
1/16 | Sachia Vickery |
6-2
3-6 2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
