Lopez, playing his record 75th successive Grand Slam, has won a five-setter in 21 of them.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2015 |
Alphen
|
1/16 | Tobias Kamke |
3-6
2-6 |
| 2015 |
Scheveningen
|
1/16 | Adrian Ungur |
6-7
3-6 |
| 2015 |
Topshelf Open, Qualification
|
1/8 | Pierre-Hugues Herbert |
6-3
6-4 |
| 2015 |
Topshelf Open, Qualification
|
1/16 | Thomas Schoorel |
6-2
3-6 6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/16 | Andrey Rublev |
7-5
6-2 6-3 |
| 2021 |
Australian Open ATP
|
1/32 | Feliciano Lopez |
5-7
3-6 6-3 7-5 6-4 |
| 2021 |
Great Ocean Road Open
|
1/32 | Kevin Anderson |
4-6
5-7 |
