Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2013 |
Sony Open Tennis, Qualification
|
1/24 (Special Qual) | Steve Johnson |
6-4
7-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
1/16 | Prajnesh Gunneswaran |
6-4
6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
