Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Sardegna Open, Qualification
|
1/8 | Cedrik-Marcel Stebe |
6-2
6-3 |
| 2021 |
Mexican Open, Qualification
|
1/8 | Frederico Ferreira Silva |
6-4
3-6 6-3 |
| 2021 |
Mexican Open, Qualification
|
1/16 | Cedrik-Marcel Stebe |
2-6
0-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
