Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2018 |
Tianjin Open, Qualification
|
1/12 (Special Qual) | Sabine Lisicki |
6-2
6-1 |
| 2018 |
Tashkent Open
|
1/16 | Vera Lapko |
1-6
3-6 |
| 2018 |
US Open, Qualification WTA
|
1/32 | Anastasia Potapova |
6-7
3-6 |
| 2018 |
US Open, Qualification WTA
|
1/64 | Bojana Jovanovski |
6-4
6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
