Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2018 |
Hopman Cup, Group B
|
Championship | Roger Federer |
7-6
7-5 |
| 2017 |
Nitto ATP World Tour Finals, Group Boris Becker
|
Championship | Roger Federer |
6-4
7-6 |
| 2017 |
BNP Paribas Open
|
Semi Finals | Roger Federer |
1-6
6-7 |
| 2015 |
Swiss Indoors Basel
|
Semi Finals | Roger Federer |
6-3
6-4 |
| 2015 |
BNP Paribas Open
|
1/8 | Roger Federer |
3-6
2-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Qatar Open
|
Quarter Finals | Nikoloz Basilashvili |
3-6
6-1 7-5 |
| 2021 |
Qatar Open
|
1/8 | Roger Federer |
6-7
6-3 5-7 |
| 2020 |
Australian Open ATP
|
Semi Finals | Novak Djokovic |
6-7
4-6 3-6 |
| 2020 |
Australian Open ATP
|
Quarter Finals | Roger Federer |
3-6
6-2 6-2 6-7 3-6 |
| 2020 |
Australian Open ATP
|
1/8 | Roger Federer |
6-4
1-6 2-6 2-6 |
| 2020 |
Australian Open ATP
|
1/16 | Roger Federer |
6-4
6-7 4-6 6-4 6-7 |
| 2020 |
Australian Open ATP
|
1/32 | Roger Federer |
1-6
4-6 1-6 |
| 2020 |
Australian Open ATP
|
1/64 | Roger Federer |
3-6
2-6 2-6 |
| 2019 |
Nitto ATP World Tour Finals Final Stage
|
Championship | Stefanos Tsitsipas |
6-3
6-4 |
