Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Shanghai Rolex Masters
|
1/32 | Alexandr Dolgopolov |
6-4
1-6 1-2 |
| 2016 |
Hopman Cup, Group A
|
Championship | Alexandr Dolgopolov |
6-4
6-2 |
| 2014 |
Rakuten Japan Open Tennis Championships
|
1/16 | Jack Sock |
6-4
6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Tallahassee
|
1/16 | Jason Jung |
6-2
3-6 4-6 |
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2018 |
Internazionali BNL d'Italia
|
1/32 | Novak Djokovic |
6-1
6-3 |
