Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2020 |
US Open ATP
|
1/64 | Jack Sock |
3-6
6-4 6-2 4-6 7-6 |
| 2019 |
US Open ATP
|
1/64 | Pablo Cuevas |
4-6
5-7 6-7 |
| 2018 |
Mutua Madrid Open
|
1/32 | Pablo Cuevas |
6-7
6-4 6-0 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Australian Open ATP
|
1/32 | Alex de Minaur |
3-6
3-6 5-7 |
| 2021 |
Australian Open ATP
|
1/64 | Pablo Cuevas |
6-4
4-6 6-2 6-2 |
| 2021 |
Great Ocean Road Open
|
1/8 | Hubert Hurkacz |
7-5
7-5 |
| 2021 |
Great Ocean Road Open
|
1/16 | Pablo Cuevas |
5-7
3-6 |
| 2021 |
Great Ocean Road Open
|
1/32 | Pablo Cuevas |
6-4
6-2 |
