Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2013 |
Delray Beach International Tennis Championships
United States, Florida, Delray Beach |
1/16 | Jack Sock |
3-6
3-6 |
| 2011 |
Aptos
|
Championship | Matthew Ebden |
4-6
6-3 6-4 |
| 2011 |
Dallas
|
Championship | Matthew Ebden |
6-7
6-3 6-1 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Tallahassee
|
1/16 | Jason Jung |
6-2
3-6 4-6 |
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
1/16 | Prajnesh Gunneswaran |
6-4
6-1 |
