Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2014 |
BNP Paribas Open
United States, California, Indian Wells |
1/64 | Tim Smyczek |
6-4
1-6 6-4 |
| 2013 |
Rogers Cup, Qualification
|
1/14 (Special Qual) | Jack Sock |
2-6
6-3 3-6 |
| 2012 |
Champaign
|
Final | Tim Smyczek |
6-2
6-7 5-7 |
| 2012 |
Delray Beach International Tennis Championships, Qualification
|
Quarter Finals | Tim Smyczek |
7-6
6-2 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Tallahassee
|
1/16 | Jason Jung |
6-2
3-6 4-6 |
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2019 |
Citi Open
|
1/16 | Milos Raonic |
6-1
6-4 |
| 2019 |
Citi Open
|
1/32 | Tim Smyczek |
4-6
4-6 |
| 2019 |
Citi Open, Qualification
|
1/6 (Special Qual) | Tim Smyczek |
6-7
7-5 3-6 |
| 2019 |
Citi Open, Qualification
|
1/12 (Special Qual) | Tim Smyczek |
6-4
6-2 |
