Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2017 |
Rolex Paris Masters
|
1/8 | Jack Sock |
7-6
6-3 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Orlando
|
Quarter Finals | Christian Harrison |
6-7
3-6 |
| 2021 |
Orlando
|
1/8 | Jack Sock |
3-6
4-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Monte Carlo Masters
|
1/8 | Alejandro Davidovich Fokina |
2-6
6-7 |
| 2021 |
Monte Carlo Masters
|
1/16 | Lucas Pouille |
5-7
6-2 3-6 |
| 2021 |
Monte Carlo Masters
|
1/32 | Lucas Pouille |
3-6
4-6 |
| 2021 |
Andalucia Open
|
1/16 | Richard Berankis |
4-6
7-6 5-7 |
| 2021 |
Biella 4
|
1/8 | Illya Marchenko |
4-6
3-6 |
| 2021 |
Biella 4
|
1/16 | Lucas Pouille |
6-2
7-6 |
