Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2012 |
Farmers Classic
|
1/16 | Igor Sijsling |
6-7
3-6 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Oeiras
|
Quarter Finals | Marco Trungelliti |
6-3
6-4 |
| 2021 |
Zadar
|
1/16 | Gianluca Mager |
6-4
4-6 6-4 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Miami Open
|
1/64 | Yannick Hanfmann |
5-7
2-6 |
| 2021 |
Mexican Open
|
1/16 | Laslo Djere |
2-6
3-6 |
