Isner lost his fourth-round match to Roberto Bautista Agut in Miami on Tuesday.
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Monte Carlo Masters, Qualification
|
1/14 (Special Qual) | Salvatore Caruso |
3-6
4-6 |
| 2021 |
Marbella
|
Quarter Finals | Alessandro Giannessi |
0-6
3-6 |
| 2021 |
Marbella
|
1/8 | Martin Klizan |
3-6
3-6 |
| 2021 |
Marbella
|
1/16 | Martin Klizan |
1-6
6-7 |
| year | Event | RND | Winner | Results |
|---|---|---|---|---|
| 2021 |
Biella 4
|
1/16 | Andreas Seppi |
6-4
3-6 3-6 |
